Rotherham sit two places above the Chairboys who will try and close the gap on their relegation rivals.
There is a five point gap between the two teams but Rotherham have a significant amount of games in hand.
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Gareth Ainsowrth believed his side are now a better team than they were in the reverse fixture where The Millers that snacthed all three points late on in the opening game of the season.
The Wycombe boss said: "That first game of the season against Rotherham here was a real blood, guts and thunder game and it was decided via a set play which we conceded right near the very end.
"We feel we were better than that on the day and we can hopefully we can show them that at the New York Stadium."
A win will see the Chairboys win back to back games since the beginning of November.
Ainsworth continued: "It will be a big game.
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"They will want to put distance between us and them and we want to reduce that distance.
"It is got the billing of a great game and I am looking forward to it.
“They are a good side with a good manager and they are structurally solid at what they do but, I have players who can pick their locks."
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